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According to our structure, the octanoyl group is located at cavity II but not cavity I, which is different from the previous modeling studies 17,18,19

This activation of the PI3K pathway could trigger Protein Kinase B (Akt), a potential enzyme within this pathway that may influence the movement of glucose transporters to the plasma membrane, potentially increasing the uptake of glucose by cells

Innovation 3 , 100328 (2022)

Losa M, Schopohl J, von Werder K

These data support the calculation of the Maximum Recommended Starting Dose (MRSD) the starting dose for the first administration in humans, derived from preclinical data and converted to a human equivalent dose using internationally agreed methods