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doi: 10.1083/jcb.201006052 85 DoudaDNKhanMAGrasemannHPalaniyarN

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397 Conventional anticancer agents Chemotherapeutic drugs (e.g., Doxorubicin, Paclitaxel, Cyclophosphamide, and 5-Fluorouracil) often induce ROS via a secondary mechanism (including mitochondrial dysfunction, DNA damage, depletion of NAD + and ATP, and destabilization of microtubules) to enhance their cytotoxic effects

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This IGF-1 is then released into the bloodstream, where it exerts its growth-promoting effects on various other tissues

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