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When young patients present with genital melanosis, the oral mucous membranes should be inspected for the presence of similar pigmentation

If the evaluation results show that the entire lesion has not been removed, the remaining part of the lesion will need to be taken for further evaluation

You get the desired effect with a much lower risk of confounding variables from off-target receptor activation

Epidemiology Dysplastic nevi are relatively common in the general population.8 Reports have described the prevalence ranging from 2% to 53% in different studies, depending on the diagnostic criteria (clinical or histological).8 A more accurate estimate is considered to be about 2%-8% of Caucasians, with a predilection for young individuals (less than 30 to 40 years of age).18 The frequency of dysplastic nevi in patients with a history of melanoma is much higher: 34% to 59%.18 Evidence suggests that sun exposure, in addition to genetic susceptibility, may increase the appearance of such nevi.1,8,18 Data concerning the prevalence of AMS are difficult to document in part due to the large variability in the diagnostic criteria employed by different studies

Although AMN infrequently progress to melanoma, the larger the number of atypical (and typical) melanocytic naevi, the greater the risk