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Int J Radiat Oncol 59:1491-1504, 2004

In myofibroblasts, however, TGF- upregulates GLS1 expression via Smad3 and p38 and promotes myofibroblast differentiation ( Tryptophan metabolism, especially in immune cells, exemplifies another aspect of amino acid metabolism modulated by TGF- signaling (Table 1C)