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These synergistic effects provide a promising theoretical foundation for the development of integrated therapeutic approaches combining Chinese herbal medicine with personalized exercise interventions, offering a novel and practical strategy for the management of ALD within both clinical and rehabilitative contexts

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CXCL2 activates the NOTCH/recombining binding protein suppressor of hairless (RBPJ) signaling pathway, leading to upregulation of CD44 on monocytes

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It influences anti-inflammatory pathways, including downregulation of cytokines (Tumor Necrosis Factor-alpha and Interleukin-6), which are responsible for promoting tissue swelling and damage