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The reason I find the Trojan horse frame useful is that it shifts the conversation from should I be worried about plastic particles to what is the full biological burden of living in a plastic-saturated environment, and the latter is a more tractable and clinically actionable question

10.1038/nrc3495 161 TuncerC.HaciogluC

102 HeY.WilsonJ.SuC.WilkinR

Spatial genomics enables multi-modal study of clonal heterogeneity in tissues

162 Furthermore, S1PR inhibits extrathymic and innate Treg cell production while driving Th1 development in a reciprocal manner, which is reciprocally regulated by S1P1-mTOR and the opposing TGF--Smad3 signaling