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LPS activates NF-B signaling through the TLR4/CD14-MyD88-dependent pathway, inducing excessive production of pro-inflammatory cytokines such as TNF- and IL-6, triggering systemic low-grade chronic inflammation (93)

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Disclosures: Saleha Aziz: Nothing to Disclose, Arsalan Hamid: Nothing to Disclose, Michael Hall: Nothing to Disclose, Mark Pedersen: Nothing to Disclose, Jan Petrasek: Nothing to Disclose 2037 HEPATIC STELLATE CELL-DERIVED THBS2 PROMOTE INTRAHEPATIC INFLAMMATORY INFILTRATION BY REGULATING SPP1 SECRETION DURING LIVER FIBROGENESIS Hong Li 1 Ning Zhang 2 Wen Zhang 1 Wenyue Wu 1 Yameng Sun 1 Shuyan Chen 1 Qi Han 1 Xuzhen Yan 3 Aiting Yang 1 Hong You 1 Wei Chen 1 , 1 Beijing Friendship Hospital,Capital Medical University, 2 Beijing Friendship Hospital, Capital Medical University, 3 Beijing Friendship Hospital, Capital Mdeical University Background: Our previous study demonstrated that Thrombospondin-2 (THBS2) plays a critical role in hepatic stellate cells (HSCs) activation and the progression of liver fibrosis through TLR4-FAK/TGF- signaling

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Zia A, Farkhondeh T, Pourbagher-Shahri AM, Samarghandian S