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In addition to cofactor requirements, some HDACs need to be in multi-protein corepressor complexes to achieve their full catalytic function

The partner protein Cockayne syndrome A (CSA, also known as ERCC8) and CSB (also known as ERCC6) ubiquitylation the Cterminal domain of RNA polymerase II, which arrested in the damaged coding region and initiated the normal NER through GGR signaling [36, 37]

To investigate, Huiying Li, a molecular pharmacologist at the University of California-Los Angeles, and her team decided to focus on high levels of B12 as a possible culprit, based on research from the past six decades that's linked it to higher instances of the condition