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The reasoning is to establish a gastroprotective baseline before exposing the GI tract to the motility changes that semaglutide induces

These frameworks allow simultaneous testing of multiple therapies or targets within a shared infrastructure, reducing redundancy and accelerating discovery

145 Under hypoxia, elevated HIF-2 upregulates SDF-1/CXCR4 in pericyte cells, promoting pericytes to migrate from capillaries to arterioles, where they increase the expression of Calponin and SM22, transforming into smooth muscle cell (SMC)-like cells and contributing to vascular remodeling