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The few vitamin E studies that included a placebo treatment group revealed that vitamin E did not appear to produce better results than the placebo, raising the question of whether vitamin E is an effective treatment

Tolerance (i.e., need for increased amounts or diminished effect with continued use of the same amount)* Experiencing withdrawal (opioid withdrawal syndrome) or taking opioids (or a closely related substance) to relieve or avoid withdrawal symptoms.* *Patients who are taking opioids as prescribed by a healthcare provider may experience tolerance and withdrawal, but in that case, do not have opioid use disorder

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(2023) studies, which we identified in the CY 2026 OPPS/ASC proposed rule, have substantial limitations

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