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The insulin signalling system and the IRS proteins

doi: 10.3389/fimmu.2025.1602235 Received 29 March 2025 Accepted 19 May 2025 Published 04 June 2025 Volume 16 - 2025 Edited by Yali Zheng, Xiamen University, China Reviewed by Hong Yu, Nanyang Technological University, Singapore Jiaxin Ma, Xiamen University, China Updates Copyright 2025 Habiballah, Li and Jiang

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The passage of the polypeptide into the endoplasmic reticulum (ER) removes the signal peptide, while the nascent IGF-1 prohormone (proIGF-1) is emerging, retaining the E-domain

Although emerging evidence suggests that both aging and chronic hyperglycemia activate the HBP in ECs, the direct impact of age-associated HBP remodeling on vascular dysfunction remains insufficiently characterized