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doi: 10.3389/fphar.2023.1339057 89 ZhangM.LyuD.WangF.ShiS.WangM.YangW.et al

The controversial outcomes of mTOR inhibitors in sepsis clinical trials highlights the extreme importance of the intervention timing and immune-metabolic stratification of patients-inhibiting mTOR during the immunosuppressive stage may further impair T-cell function and exacerbate the condition (56)