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This is primarily due to rectification of aberrant circadian rhythm by improvement of sleep quality associated with risk development of neurodegenerative, cognitive, cardiovascular and other metabolic disorders, thereby enhancing the quality of life

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[DOI] [PubMed] [Google Scholar] (186).Barenholz Y Doxil The first FDA-approved nano-drug: Lessons learned

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Furthermore, the solutions to regulate excessive TMAO levels from the perspective of diet, TMAO/TMA circulation, and gut microbiota regulation are reviewed, providing a promising targeted therapy for CVDs