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Another critical challenge involves the lack of standardized research methodologies, including inconsistency in dosing strategies, routes of administration, treatment durations, and outcome measures

doi: 10.1111/jdv.19069 157 SongX.WuX.WangC.SunS.ZhangX

Three reasons opioid use depletes NAD: Oxidative stress Mitochondrial dysfunction Increased enzyme activity (PARPs, CD38) Regular opioid use has been linked with oxidative stress (an imbalance of free radicals and antioxidants) and mitochondrial dysfunction (problems with the cells power plants that help produce energy)

S-allyl cysteine, a garlic compound, produces an antidepressant-like effect and exhibits antioxidant properties in mice

Saat K, Kowalczyk P, Gryzo B, Jakubowska A, Kulig K