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Others suggest additional benefits such as antimicrobial and antioxidant activities, enhanced immunity, and reduced inflammation

However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

Researched for Preclinical (mouse-only) metabolic research as a selective inhibitor of NNMT (nicotinamide N-methyltransferase)

The one thing not to do is stop or change a prescribed course suddenly on your own, especially where the cause is non-dietary and the treatment is lifelong

It is not FDA-approved for general weight loss, but can be used off-label in personalized medicine settings under provider supervision