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Interestingly, in individuals with HVDAS, the ADNP-SIRT1-EB1/EB3 protein complex may regulate autophagy, which is dysregulated and negatively affects mitochondrial metabolism in autism [344]

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The transmission of the stress signal from one leaf to its neighbors addresses the need for coordination of the response of all organs of a plant to that stress (systemic response)

Alkylation of the proteins was achieved by adding 3.5 l of 100 mM iodoacetamide (IAM) to the samples followed by agitation using a shaker (1200 rpm) at 37 C for 15 min