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LPS activating microglia via TLR4 as earlier described) [196]

The paper thoroughly explores the use of nanomaterials as drug delivery systems (DDSs), imaging contrast agents, and therapeutic tools, with particular emphasis on multifunctional nanoplatforms that integrate diagnostics and therapy

An increased proportion of PUFAs in normal diet also induces oxidative stress (increased malondialdehyde [MDA]), reduces cellular defense against oxidative stress (metallothionein) in the liver, and promotes oxidative degradation of DNA (elevated 8-hydroxy-2-deoxyguanosine levels serum) in a content-dependent manner despite increased fat oxidation and decreased fat synthesis [80]