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The profiling was also performed using the TMT-LC/LC-MS/MS method 46,47,48,49 , with an additional step of phosphopeptide enrichment to improve the phosphoproteome coverage 55 (Supplementary Fig

Hence, it is logical to hypothesize that masking of the terminal NH 2 group by making a labile chemical derivative of INH, i.e., a derivative which can release INH back when exposed to biofluid in gut or blood (owing to hydrolytic activity of esterase/amidase) can limit known metabolic biotransformations of INH (Figure 6)

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10.3389/fphar.2022.873646 237 YeS.MaoB.YangL.FuW.HouJ

Wang, J., Zhang, A., Ye, M