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Figure 4 The omega-3 fatty acid EPA downregulates mRNA levels and cellular protein levels of selected virulence factors in outbreak isolates of L

Many of the genes encoding ICE-like proteases, henceforth referred to as caspases, were isolated by molecular cloning

The 5-LOX inhibitor, zileuton, is however, approved for treating asthma which could be repurposed as TB HDT and tested to elucidate whether modulation of this pathway improves TB treatment outcomes