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[5] The pathophysiology of anaphylaxis and anaphylactoid reactions stems from the effect of histamine on vascular and bronchial smooth muscle leading to cutaneous vasodilation and third-spacing (hives, rash, pruritis), bronchospasm (wheezing), and reduced systemic vascular resistance (tachycardia, hypotension)

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Illustration of the cytokinedriven mechanisms underlying joint destruction in rheumatoid arthritis

[DOI] [PubMed] [Google Scholar] 2.Roberts MR et al

4A, B), whereas NRF2 ectopic overexpression increased the expression of CBS along with antioxidant factors such as NQO1 and GCLC (Fig