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Soldevila-Domenech N, Forcano L, Vintr-Alcaraz C, Cuenca-Royo A, Pint X, Jimnez-Murcia S, et al

DPP-4i could restore the inactivation of AKT and ERK signaling and inhibit NF-B activation to reduce the production of pro-inflammatory factors, including TNF-, IL-1, monocyte chemoattractant protein-1 (MCP-1), ICAM-1 and TGF- (169, 170)

This disorder of acylcarnitine metabolism promotes a continuous inflammatory response and thus plays a key role in the pathological process of N-ERD [45]