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EN is associated with prolonged hospitalization and high healthcare costs.3 The most important aspect of EN treatment is discontinuation of treatment with the causal agent, admission to a specialist intensive care unit with experience in managing this condition, and provision of appropriate support measures.4 Treatment of EN is the subject of some controversy: corticosteroids, classical immunosuppressants, monoclonal anti-TNF- agents, immunomodulators such as immunoglobulins, and plasmapheresis have all been used without clear evidence of effectiveness

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Nature (2000) 405(6790):106973.10.1038/35016611 126 StarrRWillsonTAVineyEMMurrayLJRaynerJRJenkinsBJet alA family of cytokine-inducible inhibitors of signalling