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While the 10.612.8% mean weight reduction at 24 weeks was clinically significant, the risk-benefit calculus for a chronic weight loss medication with sympathomimetic cardiovascular effects didnt meet regulatory safety thresholds

23 Come hell or high water This idiom about water is commonly used to say that a person will do something no matter what

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Specifically, we sought comment on what criteria we could add, reflecting clinical practice, that would determine the costly additional components that are often associated with other high-cost packaged items and services