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doi: 10.1056/NEJMra043430

Chronic stress and inflammatory stimuli promote microglial activation, leading to sustained release of pro-inflammatory cytokines, reactive oxygen and nitrogen species, and excitotoxic mediators that disrupt synaptic function and neuronal integrity (30)

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However, clinical trials suggest that the side effects of TB500 are generally considered mild and rare, particularly when used at appropriate dosages

de Rey-Pailhade over 100 years ago, and its structure (ie, L-g-glutamyl-L-cysteinyl-glycine, or g-Glu-Cys-Gly), was deduced in the 1930s