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doi: 10.1016/j.neuint.2019.02.019 201 GuoJDZhaoXLiYLiGRLiuXL

AML cells are completely dependent on exogenous GLN, and knockdown of high-affinity ASCT2 leads to apoptosis in AML cell lines and inhibits tumor progression in AML xenografts and primary AML mouse models [47] Indeed, ASCT2 plays pleiotropic roles in cellular metabolism and serves as a promising molecular target for the treatment of leukemia [27]

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In this regard, we need to closely combine different disciplines, research models and characterization tools to deeply reveal the molecular mechanisms of MSNs-based nanomedicines and elucidate the action behavior between materials and biological interfaces

Each transporter will be dealt with and described in terms of its role in the derangements occurring in cancer cells