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Ubiquitin is a key covalent modification mechanism, which covalently links ubiquitin peptide chains containing 76 amino acids to lysine residues of histones through the continuous action of the E1 activating enzyme, E2 binding enzyme and E3 ligase (6)

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The NF-B also can impact the level of ROS by modulating the expression of SOD1/SOD2, Glutathione S-transferase pi (GST-pi) and Gpx1 [64]

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