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Why Delivery Matters More Than You Think One reason topical GHK-Cu efficacy varies so much between users is that the peptide struggles to penetrate intact skin

De Luca C, Lievore G, Bozza D, Buratti A, Cavazzini A, Ricci A, et al

Science 312 , 117121 (2006)

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The expression of proteins filaggrin (FLG) and loricrin (LOR) was evaluated by immunofluorescence, while the expression of mRNAs FLG and LOR in the skin was measured via qRT-PCR