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HGF/c-Met signaling is a well-established oncogenic pathway: c-Met is amplified or overexpressed in multiple cancers (gastric, lung, renal, hepatocellular) HGF/c-Met activation promotes tumor cell proliferation, survival, invasion, and metastasis c-Met inhibitors are FDA-approved cancer drugs (cabozantinib, crizotinib, capmatinib) A compound that potentiates HGF/c-Met signaling raises theoretical concerns about promoting tumor growth or transformation with chronic use

Furthermore, when PBMCs from healthy controls were suspended in plasma from ME/CFS patients, the impedance pattern resembled that of ME/CFS patients [1]

doi:10.1001/jamanetworkopen.2021.27403 COVID-19 Resource Center Key Points Question What are the long-term health outcomes associated with COVID-19 infection 1 year after hospital discharge

Three Minute Outcomes 4

Many administrators prefer to use urine tests because of the accuracy and simplicity of the process