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OBS ameliorates mRNA and protein expression increased by CIS by the Nrf2/HO-1 pathway The effects of OBS and CIS treatments on the expression of genes associated with the Nrf2/HO-1 signaling pathway (Nrf2, HO-1, TNF-, and NFB) and the apoptotic process (Bcl-2, Cas-3, and Bax) were examined in the liver (Fig