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NNMT inhibitors may be used with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels, to produce synergistic or additive effects to provide muscular therapy

Many patients report reduced pain intensity, fewer attacks, improved quality of life when working with a skilled practitioner on a combined treatment plan

Anaemia due to Iron deficiency Please note that this guidance also applies to those with proven iron deficiency without anaemia, but please see below about the need for GI investigations

Last reviewed: June 4, 2026 Last updated: June 4, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

For most patients, side effects are manageable and temporary