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J Rheum Dis 2011;14:122 2

Patients on GLP-1 therapy often remain in a low-grade inflammatory state during the active weight loss phase, which can slow the very tissue remodelling that would otherwise benefit from reduced adiposity

Ethics declarations Conflict of interest The authors have no competing interests to declare that are relevant to the content of this article

The BTB domain binds CUL3 and is used to link to E3 ubiquitin ligase, the IVR domain regulates cysteine residue activity, and the Kelch repeat domain is mainly responsible for linking to Nrf2 (Fig

The antioxidant power of the intestine was compromised due to inhibition of key antioxidant enzymes and decreased reduced glutathione levels which led to impaired free radical quenching and metal-reducing ability