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Phase 2, multicenter, open-label study of tigatuzumab (CS-1008), a humanized monoclonal antibody targeting death receptor 5, in combination with gemcitabine in chemotherapy-naive patients with unresectable or metastatic pancreatic cancer

Prior research has demonstrated the importance of intact TDLNs to the response to PD-1 blockade (73)

In vivo assessments conducted in a rotenone-induced PD animal model revealed notable improvements in motor function and coordination

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Shank postsynaptic scaffolding proteins in autism spectrum disorder: Mouse models and their dysfunctions in behaviors, synapses, and molecules