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MnO 2 NPs can also be used as a unique nutrition-responsive ICD inducer, selectively inducing ICD in nutrition-deficient tumor cells to regulate adaptive immunity (110)

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It helps maintain cellular homeostasis by modulating oxidative stress, assisting in protein repair, supporting mitochondrial function, sustaining DNA integrity, and influencing inflammatory pathways

The study highlights that PEGylated PLGA nanoparticles, could offer a promising alternative for the safe delivery of tolcapone, maintaining its therapeutic effects while significantly reducing associated hepatotoxicity 129