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10.1038/s41419-021-04367-3 197 YangM.WuX.HuJ.WangY.WangY.ZhangL.et al (2022)

Genetics, sun exposure, and lifestyle all play a role

Furthermore, anticholinergic medications, such as trihexyphenidyl, are used also in PD management but struggle to effectively cross the BBB and often exhibit non-specific binding, leading to undesirable peripheral effects such as dry mouth and cognitive impairment, particularly in elderly patients

More recent research has identified the major site(s) of superoxide generation within mitochondria and it is generally agreed that complexes I and III of the electron transport chain are the primary locations of mitochondrial superoxide production (44, 277)