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The mobile phase comprised of methanol: water in a 4:96 ratio, 50 mM sodium citrate and 50 mM acetic acid (pH 3.1)

To more faithfully model the BBB in PD, in-vivo models are required

This subsection explores therapeutic strategies designed to boost synaptic adaptation, including receptor modulation, epigenetic tuning, and activity-based interventions

However, in certain diseases, low methylation of the LINE-1 promoter leads to its overexpression, which in turn activates immune factors such as IFN-I, resulting in immune dysregulation and inflammatory responses (Mavragani et al., 2016)

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