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MCOLN1/ cells show obvious Fe 2+ deposition in lysosomes and cause cellular iron metabolism disorder and neuronal degeneration (Dong et al., 2008)

In preclinical research settings, experimental models may examine its role in pathways associated with oxidative stress regulation, detoxification mechanisms, and cellular response systems

Park HK, Kim SM, Choi CG et al (2008) Effect of trientine on manganese intoxication in a patient with acquired hepatocerebral degeneration

For example, glutamate is subsequently converted to -ketoglutarate (-KG), a key metabolite that stimulates mTORC1 via its interaction with prolyl hydroxylases, which increases the GTP loading of Rag GTPases responsible for mTORC1 activation

About 10 mg/kg of paraquat dose was administered intraperitoneally on weekly basis for 3 consecutive weeks