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Although no NF-B inhibitors have been approved to the clinical treatment for MS, the beneficial effects of NF-B interference by a considerable number of natural components (e.g., piperlongumine and denanthin) have been suggested in basic animal studies (120, 121)

More promising, perhaps, are multi-target approaches that simultaneously enhance EAAT2 function and reduce oxidative stress, potentially offering a more robust neuroprotective effect [403]

Recent estimates suggest that global ED prevalence spans from approximately 376.5%, largely reflecting differences in assessment tools (for example, the International Index of Erectile Function versus Massachusetts Male Aging Study questionnaires) and the demographic and clinical characteristics of study populations

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There are many studies that have examined the link between antioxidants and inflammatory and oxidative pathways