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If NNMT inhibition both restores adipocyte energy expenditure (promoting fat reduction) and supports myogenic differentiation (preserving or enhancing muscle), the net body composition effect could be recomposition simultaneous fat loss and lean mass preservation

Before we dive into the ban, we need to be clear about what we're discussing

Semaglutide, the latter emerges as the preferred option

Modest weight loss often produces substantial symptom improvement independent of other interventions