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Similarly, rbohF and rbohD/F mutants infected by TuMV had increased activity of GST and GR, strongly downregulated GPXL, and highly reduced levels of lipid peroxidation

ATP production analysis The ENLITEN ATP Assay System (Promega, Madison, WI, USA) was used according to the manufacturers instructions

Z is independently selected from the group consisting of one or more amino acid(s), one or more N-substituted amino acid, optionally substituted polyether, C1-C12 alkylene, arylene having 6 to 10 ring atoms, C3-C8 cycloalkylene, heterocycloalkylene having 5 to 10 ring atoms, heteroarylene having 5 to 10 ring atoms, C2-C10 alkenylene, and any combination thereof, said alkylene and alkenylene being optionally interrupted by one or more heteroatom or chemical groups selected from -O-, -S-, -C(O)-, -NR-, -C(O)NR- , -NR-C(O)-, -NR-C(O)-NR-, -NR-C(O)-O-, -O-C(O)NR- and triazole, and said alkylene, arylene, cycloalkylene, heterocycl R, R and R being independently selected from H and Ci-Ce alkyl

Its actions, from the direct inhibition of cell migration to the proteolytic activation of key substrates like endoglin and OPN, create a permissive environment for tumor growth and spread