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In the process of hepatocellular steatosis, one of the hallmarks of MASLD is the appearance of the UPR in hepatocytes, which can inhibit mitochondrial lipid oxidation through the UPR-induced ATF-6 pathway and promote fatty acid synthesis via the PERK, ATF-6 and IRE1 signaling pathways, which together promote intracellular lipid accumulation (67,68)

In hot, humid regions of Africa and Asia with improper grain storage facilities, high levels of dietary AFB 1 are associated with increased risk of hepatocellular carcinoma

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Cancer Causes Control 2001;12(4):317-324

Inhibition of the expression of the stemness-related genes OCT4 and NANOG and suppression of proliferation and migration via regulation of the expression of markers of the EMT process were observed [95]