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Ethics declarations Acknowledgements This work was undertaken as part of UK Biobank project application ref 56653 Pharmacogenomics to improve drug efficacy and safety

Fideles, S

As described in detail elsewhere (Reference Whelan and Savva24) , the first wave of data collection (wave 1, 20092011) was conducted using a stratified clustered procedure to randomly sample postal addresses from the Irish Geo-Directory (a listing of all residential addresses in the Republic of Ireland)