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Studies have shown that in the skeletal muscle of severely dyslipidemic transgenic mice and in a pro-oxidative and pro-inflammatory state, GPx1 is hypermethylated, which decreases GPx1 expression and weakens the endogenous antioxidant defense

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MITOCHONDRIAL ROS GENERATION AND DEFENSE Reactive oxygen species can be generated in several intracellular sites, including cytosol, peroxisomes, plasma membrane, and ER

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This work was supported by National Institutes of Health Intramural Research Program funding ZIA-DA000635 (NIDA/NIAAA Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section