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However, the cellular stress of the upstream events, i.e., reactive metabolite formation, GSH depletion, and protein adducts formation, is still present and this stress may trigger apoptosis in a limited number of cells (Figure 1)

It says that children with neurological involvement (meaning neuro symptoms) should have a b12 injection every other day until improvement stops then every 2 months The above might be a good one to show GP

Khan ZUH, Gul NS, Sabahat S, Sun J, Tahir K, Shah NS, Muhammad N, Rahim A, Imran M, Iqbal J, Khan TM, Khasim S, Farooq U, Wu J (2023) Removal of organic pollutants through hydroxyl radical-based advanced oxidation processes

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Alpha-lipoic acid supports the recycling of depleted protective substances as a water- and fat-soluble antioxidant