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Drofenine as a Kv2.1 inhibitor alleviated AD-like pathology in mice through A /Kv2.1/microglial NLRP3/neuronal Tau axis

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When the membrane lipid was peroxided, the physical properties of lipid bilayers were altered: membrane fluidity was reduced, the ion gradient was destroyed, membrane permeability was elevated, and lateral diffusion was retarded ( PUFAs in the phospholipids (PLs) of cell membranes, rather than mono-unsaturated FA, cholesterol, and cardiolipin, are highly prone to lipid peroxidation (Yang et al., 2016)

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longum APC1472 reduced the non-significant increase in gonadal and mesenteric white adipose tissue weight (normalized to body weight) induced by an early-life HFHS diet exposure in adult male mice (Supplementary Fig