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Linus Pauling Institute Oregon State University Updated in January 2012 by: Victoria J

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Sorafenib causes the production of P62, which inhibits NRF2 degradation and promotes the inactivation of KEAP1, followed by the activation of heme oxygenase-1 (HO-1), quinone oxidoreductase-1, and ferritin heavy chain-1, which enhances NRF2 nuclear localization

Glutathione bekerja dengan cara menghambat produksi melanin, pigmen yang bertanggung jawab atas warna kulit gelap atau hiperpigmentasi