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Treatment with silymarin significantly decreased AST (SMD: 0.916, 95% CI: 1.437, 0.394, p -value: 0.001) (Figure S14) and ALT (SMD: 0.847, 95% CI: 1.261, 0.432, p -value: 0.000) (Figure S15) levels in patients with non-alcoholic fatty liver diseases (NAFLD), while it had no substantial effects on liver enzymes in patients with alcoholic liver cirrhosis (Figure S14 and S15)

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Its significant inhibitory effect on immune function makes it unsuitable for treating long-term chronic diseases, including cardiac hypertrophy and heart failure [11]