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Experimental validation is essential to bridge the gap between computational predictions and clinical relevance, which will strengthen the understanding of DEHPs role in BRCA pathogenesis and inform evidence-based risk assessment of plasticizers

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Enhanced extracellular matrix deposition has also been observed, indicating regulated synthesis and assembly of key structural proteins such as collagen and elastin, which are essential for restoring tissue strength and elasticity in experimental systems

Sample sizes were generally small (median: 48, IQR 2594), reflecting both the rarity of the diseases studied and the exploratory nature of early-stage research