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We note that this enhancement did not fully restore efferocytosis to the level observed in M2 macrophages, suggesting that while the PKA-HSL axis is a critical component, other M2-specific factors also contribute to maximal efferocytosis function

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The axis GH/IGF-I is claiming a particular physiological understanding

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Published preclinical data in rodents suggests doses equivalent to 200mg+ in humans produce off-target effects on folate metabolism and S-adenosylmethionine (SAMe) pools