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MOTS-c and Metabolic Regulation MOTS-c translocates to the nucleus in response to metabolic stress, where it regulates nuclear gene expression

Laboratory studies suggest the peptide can shift gene-expression patterns toward a profile associated with younger tissue and may support the activity of cells involved in repair

Particularly intriguing was the finding that mice treated with triple therapy had a complete absence of metastases as assessed by gross morphology as well as histological examination of extrapancreatic organs (Fig

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10.1152/ajprenal.00407.2011 70 LeeM