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An increase in metHb levels and in its linkage to the RBC membrane, accompanied by ROS formation, was also found in stored RBCs for blood transfusion [30] and in exogenous H 2 O 2 -induced OS upon healthy erythrocytes [31, 32]

This observation suggests a potentially different mechanism underlying the suppressive effects of LDH inhibition in NB, it may extend beyond its recognized metabolic functions in tumorigenesis

[DOI] [PubMed] [Google Scholar] Singh R.K., Najmi A.K

Topical numbing creams like lidocaine applied 15 minutes before injection significantly reduce needle sensation